Alternative Toxicological Methods - download pdf or read online

By Harry Salem,Sidney A. Katz

ISBN-10: 084931528X

ISBN-13: 9780849315282

Bringing jointly the hot and appropriate contributions of over a hundred twenty five scientists from undefined, govt, and academia in North the United States and Western Europe, substitute Toxicological tools explores the improvement and validation of alternative, relief, and refinement choices (the 3Rs) to animal checking out. the world over well-known scientists current what has been complete to date in constructing applicable choices to standard animal toxicological evaluation and supply most likely new initiatives.

In over forty chapters, the publication addresses 7 issues, starting with the validation and regulatory recognition of possible choices within the US, the united kingdom, and Western Europe. Then the booklet covers tools according to the mechanisms of eye inflammation on the ocular floor, dermal toxicity trying out, and assessing neurotoxicity. it is also a case learn within the use of choices to figure out the mechanism of sulfur mustard motion and discusses the position of transgenics and toxicokinetics within the improvement of other toxicity assessments. eventually the publication provides contemporary thoughts in possible choices, together with using archival information, and in silico techniques.

Focusing at the technology and never the politics, replacement Toxicological equipment concisely discusses the applying of state of the art tools and explores state-of-the-art examine on the topic of constructing and validating possible choices to animal trying out. This ebook will gain toxicologists, beauty chemists, pharmacologists, experimental biologists, dermatologists, ophthalmologists, and regulatory officials of their quest for using the 3Rs to using animals in toxicological checking out of drug applicants, chemical substances, and cosmetics.

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Alternative Toxicological Methods by Harry Salem,Sidney A. Katz

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